MOTS-c 10mg

Description

MOTS-c is a 16-amino acid mitochondrial-derived peptide studied for its influence on metabolic homeostasis, insulin sensitivity, and AMPK activation.

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a unique bioactive peptide encoded within the mitochondrial genome rather than the nuclear genome. As a member of the mitochondrial-derived peptide (MDP) family, it functions as a signaling molecule that facilitates communication between mitochondria and the nucleus. Scientific literature identifies MOTS-c as a key regulator in systemic metabolic homeostasis, primarily through its influence on glucose metabolism and fatty acid oxidation. Research indicates that MOTS-c acts by activating the AMP-activated protein kinase (AMPK) pathway, a critical sensor of cellular energy status. By stimulating this pathway, the peptide is studied for its capacity to enhance insulin sensitivity and promote cellular energy expenditure. Furthermore, MOTS-c has garnered significant interest in longitudinal studies regarding cellular senescence and the physiological decline associated with mitochondrial dysfunction, making it a cornerstone for metabolic and longevity-focused research.

Product Overview

MOTS-c is a 16-amino acid mitochondrial-derived peptide. Unlike traditional hormones, it is synthesized within the mitochondria and translocates to the nucleus in response to metabolic stress. It is widely utilized in laboratory settings to investigate mitochondrial signaling, metabolic regulation, and the molecular mechanisms of energy production. All GulfBio products are strictly for laboratory research purposes only.

Specifications

Form: Lyophilized Powder Quantity: 10mg Purity: ≥99% (HPLC) Storage: Store in a cool, dry place, away from direct sunlight. Once reconstituted, laboratory samples should be kept refrigerated for stability.

Research Applications

In vitro and in vivo research involving MOTS-c primarily focuses on its role in metabolic health. Key areas of investigation include its effects on glucose uptake in skeletal muscle, its potential to counteract high-fat diet-induced insulin resistance, and its influence on thermogenesis. Researchers also utilize MOTS-c to study the mitochondrial-to-nuclear signaling axis and its impact on the aging process and physical performance capacity in murine models.

Research Use Notice

For laboratory research use only. Not for human or veterinary use.