Kisspeptin-10 5mg

Description

A potent decapeptide ligand of the GPR54 receptor, studied for its role in GnRH stimulation and HPG axis regulation.

Kisspeptin-10 is a potent truncated decapeptide derived from the parent Kisspeptin protein, encoded by the KISS1 gene. Originally identified for its role as a metastasis suppressor, Kisspeptin-10 has become a focal point in neuroendocrine research due to its critical involvement in the hypothalamic-pituitary-gonadal (HPG) axis. It functions as the primary endogenous ligand for the G protein-coupled receptor GPR54 (KISS1R), serving as a molecular switch for the reproductive system. Research into Kisspeptin-10 primarily investigates its capacity to stimulate the secretion of gonadotropin-releasing hormone (GnRH) from hypothalamic neurons. Scientific literature suggests that by activating GPR54, this peptide triggers a cascade that leads to the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Its role as a gatekeeper of reproductive development makes it an essential tool for studying puberty onset, fertility regulation, and hormonal signaling pathways in laboratory models.

Product Overview

Kisspeptin-10 (metastin 45–54) is a synthetic peptide fragment representing the minimum sequence required for full biological activity at the GPR54 receptor. In laboratory settings, it is utilized to map the intricate signaling networks of the endocrine system. GulfBio provides this compound for in vitro and laboratory research applications only, ensuring the highest standards of chemical integrity for consistent experimental results.

Specifications

Molecular Formula: C63H78N18O13 Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 Purity: ≥99% (HPLC) Format: Lyophilized White Powder Quantity: 5mg Storage: Store in a cool, dry place, away from direct sunlight. Long-term storage should be in a temperature-controlled environment to maintain peptide stability.

Research Applications

Research involving Kisspeptin-10 is centered on its efficacy in modulating the HPG axis. Published studies explore its influence on GnRH pulse frequency and its subsequent effect on downstream pituitary hormones. Additionally, researchers utilize Kisspeptin-10 to investigate its potential roles outside of the reproductive system, including its impact on metabolic regulation, thermogenesis, and its original classification in oncology as a suppressor of cellular migration.

Research Use Notice

For laboratory research use only. Not for human or veterinary use.